Moreover, hypoglycemia is a frequent side effect of therapeutic treatment with insulin, sulfonylureas or glinides, while other treatments (metformin, acarbose, thiazolidinediones, GLP-1 receptor agonists, and DPP-4 inhibitors) are capable of reducing hyperglycemia without inducing hypoglycemia. The gene discussed is DPP4; the disease is Hypoglycemia.