Activated nuclear STAT3 has been implicated in maintaining cell survival by controlling the transcription of apoptosis-regulating proteins (e.g., Cyclin D1, Bcl-X, Bcl-XL, survivin and c-Myc) thus promoting NPM1-ALK+ ALCL survival [30,31,32]. This evidence concerns the gene STAT3 and anaplastic large cell lymphoma.