Localisation studies of EML4-ALK variants 1 and 3 a/b in H2228 and H3122 patient-derived NSCLC cell lines highlight that variant 1 is localized in the cytoplasm, whereas variants 3a/b are localised to microtubules similar to full length EML4 [132,133]. The gene discussed is EML4; the disease is non-small cell lung carcinoma.