NPM1 and anaplastic large cell lymphoma: This is in marked contrast to the results of Hwang et al. (2017), which show detection of phosphorylated NPM1-ALK in both the nuclear and cytoplasmic compartments of ALCL cells [116], as well as previous research which demonstrated that NPM1-ALK forms and is catalytically active in higher-order oligomeric complexes, consistent with the finding that wildtype NPM1 forms pentameric oligomers [3,112].