Metanalysis that was conducted by Liu et al. [69] covering nine studies that were conducted throughout 2013–2016, encompassing 1886 adult patients from America and Europe, has proved the usefulness of combined TIMP-2 and IGFBP7 as reliable AKI markers, with the combined area under the ROC curve of 0.86. Here, IGFBP7 is linked to acute kidney injury.