In a small study of Wereszczyńska-Siemiątkowska et al. [79], TIMP-1 (a more potent inhibitor of MMP-9 than TIMP-2), although it was increased in patients with (mild and severe) AP in comparison.to healthy controls, was shown to be too low to inhibit the increased MMP-9 levels. The gene discussed is MMP9; the disease is alkaline phosphatase measurement.