Consistent with these results, the lower levels of IL‐1β, IL‐6 and TNF‐α in serum or uteri in the Trem1−/− mice than in the wild‐type mice after LPS stimulation suggested that the TREM‐1 gene knockout could attenuate LPS‐induced endometritis, probably by inhibiting inflammatory cytokines. Here, IL1B is linked to endometritis.