TREM1 and Down syndrome: Previous studies reported that inhibition of TREM‐1 suppressed IL‐1β‐induced chondrocyte injury, reduced colitis in mice, alleviated Streptococcus‐induced syndrome and attenuated LPS‐induced acute lung injury (Liu, et al., 2016; Kökten, et al., 2017; Tang and Dong, 2017; Han, et al., 2018).