Clinical practices have demonstrated that immune‐checkpoint blockades are more effective for colorectal cancers showing microsatellite instability (MSI) than colorectal cancers showing microsatellite stability (MSS), suggesting there are multiple pathways impairing cytotoxic T cell function besides PD1/PD‐L1, and that PD1/PD‐L1 blockades only take effect on cytotoxic T cells expressing PD1. This evidence concerns the gene CD274 and colorectal cancer.