In addition, the concentration of visfatin was higher in patients with GCP and type 2 diabetes mellitus (T2DM) compared to systemically healthy individuals with periodontal disease.8 Mohamed, et al.22 (2015) reported a positive correlation between PD and visfatin levels in GCF, and they found that visfatin increased significantly the number of diseased sites. The gene discussed is NAMPT; the disease is diabetes mellitus.