Given the occurrence of gigantism in a second-degree uncle (patient #5) and acromegaly in a second-degree aunt, an AIP gene sequencing was requested, which showed the heterozygous pathogenic variant c.504G>A in exon 4 (p.Trp168*) generating a nonsense substitution of tryptophan causing a premature stop codon. The gene discussed is AIP; the disease is acromegaly.