Several reports demonstrate that TLR4 and TLR9 polymorphism are associated with CT (TLR4: rs1927911 with PID; rs4986790 with PID, tubal pathology and genital tract infections; rs4986791 with genital tract infections; TLR9: rs5743836 and rs352140 with tubal pathology; rs5743836 with CT associated symptoms) and NG (TLR4: rs1927911 and rs4986790 with PID) infections and disease association [19,26–29]. This evidence concerns the gene TLR9 and pelvic inflammatory disease.