For example, ligation of the late T cell co‐stimulator OX40 (CD134) 37, blockade of IL‐10 receptor 38 administration of type 1 IFNs 39 TLR9 agonism 40 infection with interferon‐gamma producing C. neoformans41 enhance Th1‐ and/or Th17‐associated cytokines and improve C. neoformans clearance. Here, TNFRSF4 is linked to infection.