CACNA1A and episodic ataxia type 2: The UNC-2(C341Y) mutation in the domain I S5-S6 loop is analogous to the CACNA1A(C287Y) mutation which was shown to alter channel trafficking and kinetics in whole-cell patch-clamp recordings of transfected COS-7 cells (Wan et al., 2005), The UNC-2(L1355F) mutation in the domain IV S5-S6 loop analogous to CACNA1A (L1749P) mutation which was identified in a genome wide association study of EA2 patients (Maksemous et al., 2016).