Recent studies have revealed that sleep facilitates clearance of Aβ and Tau, two key proteins that drive AD pathology, from the brain via an accelerated ISF‐CSF bulk flow.5, 6 In contrast, following just one night of sleep deprivation, the Aβ burden in the human brain increases.30 Chronic sleep deprivation also elevates ISF Aβ levels in the mouse brain.45 Holth et al6 reported that ISF Tau is regulated by the sleep‐wake cycle, and both ISF Tau in mice and CSF Tau in humans are robustly increased by sleep deprivation. Here, MAPT is linked to Alzheimer disease.