Indeed, AQP4 deletion‐attenuated astrocyte activation has been observed in mouse models of experimental autoimmune encephalomyelitis, AD and PD, and in astrocyte culture exposed to Aβ or glutamate.18, 51, 52, 53 Particularly, previous studies have indicated that AQP4 has an intrinsic proinflammatory role during astrocyte activation. The gene discussed is AQP4; the disease is Alzheimer disease.