In turn, this promotes clearance of ISF solutes into the cerebrospinal fluid (CSF).10 Disrupted perivascular AQP4 polarization caused by reactive astrogliosis impairs glymphatic clearance, subsequently increasing accumulation of metabolic wastes in aged, AD and injured brains.14, 15, 16, 17, 18 However, the exact role of AQP4‐mediated glymphatic clearance in brain impairments following chronic sleep insufficiency remains elusive. The gene discussed is AQP4; the disease is Alzheimer disease.