CD38 and acute myeloid leukemia: CD34+CD38‐ is widely accepted as an immunophenotype of LSCs, but CD34+CD38+ cells were also found to have LSC characteristics.14 Pearce et al reported that the CD34+ and ALDH+ subpopulations in AML largely overlapped, and CD34+ALDH+ cells possess the CD34+CD38‐ and CD34+CD38+ phenotypes.22 Therefore, we did not consider CD38 expression, and we combined the CD34+ALDH+ and MRD parameters to categorize patients into four groups.