HOXA10 and cancer: Much scientific evidence indicated that the expression of genes responsible for normal embryo development was aberrant and contributed to carcinogenesis.22, 23, 24 In the past years, HOX genes emerged as transcriptional regulators responsible for embryogenesis and were involved in the development of various cancers.4 As an essential part of HOXA family genes, HOXA10 expression was crucial for ensuring normal development and differentiation of hematopoietic stem cells.25 Moreover, emerging evidence indicated that upregulation of HOXA10 was associated with different cancer types.26, 27