EGFR and head and neck cancer: Results from the Phase III multicenter Erbitux in First-Line Treatment of Recurrent or Metastatic Head and Neck Cancer (EXTREME) trial in patients with recurrent or metastatic head and neck SCC found that platinum-based chemotherapy protocols result in only a modest increase in overall survival (7.4 months), which is marginally improved with the addition of EGFR-inhibitors such as cetuximab (10.1 months) [8].