This phenomenon was associated with cancer aggressiveness.12,34 Interestingly, the growth factor IGF2, which signals through PI3K/AKT pathway is almost systematically upregulated in ACC.2,3 Although the role of IGF2 in ACC pathogenesis is still unclear,5,6 it may be involved in modulation of EZH2 activity through activation of AKT. The gene discussed is IGF2; the disease is adrenal cortex carcinoma.