PTTG1 encodes Securin, a protein involved in the G2/M transition by inhibiting separation of sister chromatids17 but also in DNA repair18 and regulation of transcription.19 It is a putative oncogene in a number of tissues such as the pituitary (where it was isolated)20 and kidney21 and was shown to be overexpressed in ACC by an independent study.22 The gene discussed is PTTG1; the disease is adrenal cortex carcinoma.