EZH2 and adrenal cortex carcinoma: Indeed, whereas knockdown of EZH2 in H295R cells results in decreased proliferation and induction of apoptosis,8 inactivation of Ezh2 in the adrenal cortex does not alter proliferation but rather modulates differentiation of steroidogenic cells.15 This suggests that ACC cells have rerouted EZH2 activity from PRC2-mediated control of differentiation to PRC2-independent stimulation of proliferation.