EZH2 and neoplasm: We have previously shown that the methyltransferase EZH2 was the most deregulated epigenetic regulator in ACC and that it was associated with tumour aggressiveness.8 Although EZH2 is the catalytic component of PRC2 complex that deposits the H3K27me3 repressive histone mark, recent data suggest that EZH2 can also stimulate transcription by interactions with a number of transcription factors.