PRC1, also known as ASE1, encodes another key regulator of mitosis, which binds microtubules and is essential for the formation of the midzone bundle, central spindle organisation and subsequent cytokinesis.23,24 It is associated with cancer progression and WNT pathway activation in a number of tissues.25,26 RRM2 encodes one of the small subunits of ribonucleotide reductase (RR), the rate limiting enzyme for production of deoxyribonucleotides. This evidence concerns the gene RRM2 and cancer.