E2F1 and cancer: Interestingly, collaboration between EZH2 and E2F1 was also found to regulate the majority of these genes in diffuse large B-cell lymphomas, suggesting that this activity was generally found in cancer.35 In contrast, even though we showed functional interaction between EZH2 and E2F1 in ACC, only six out of 56 CRPC genes were also found in our list of EZH2/E2F1 targets (Supplementary Table 7).