Therapeutic management of colorectal cancer (CRC) has changed dramatically over the last few decades with the addition firstly of oxaliplatin and irinotecan to the chemotherapeutic mainstay of fluoropyrimidine with leucovorin, and then subsequently with the use of targeted biological therapies including anti-epidermal growth factor receptor (EGFR) and anti-angiogenic agents, both of which have considerably improved survival outcomes. This evidence concerns the gene EGFR and colorectal cancer.