MKI67 and neoplasm: The CD31 and Ki67 staining results served as further confirmation that the entire tumor needs to be treated, given that the remaining viable tumor in the treated mice displayed no reduction in MVD or proliferative potential, although the CD31 results may be influenced by the time point at which the animals were sacrificed (Day 14) given that there will be some lag time between vessel occlusion and the vessel pruning and regression process55.