We found that EIF3A expression was significantly increased in HCC tissues from H-ras12V transgenic (H-ras12V-Tg) mice, another model of human liver cancer20,35, by two-fold (Fig. 2A), compared to normal tissues when detected by a commercial antibody for EIF3A (p < 0.0005) as well as XC90 antibody (p < 0.005). This evidence concerns the gene EIF3A and hepatocellular carcinoma.