Furthermore, published work has revealed cancer-specific altered splicing patterns in various cancer types (e.g. Hodgkin lymphoma, colon cancer and lung cancer) and identified several splicing factors that act as oncoproteins and contribute to tumour initiation (e.g. hnRNP E1, SF2/ASF and SRSF6)9–16. This evidence concerns the gene SRSF1 and malignant colon neoplasm.