However, intriguingly, our results on METTL3 in bladder cancer, and the METTL14 results in uterine cancer suggest that they act as tumor suppressor genes, whereas the data on METTL3 in myeloid leukemia cell lines are more consistent with an oncogenic role, with depletion inducing cell differentiation and apoptosis41. Here, METTL3 is linked to urinary bladder cancer.