EWSR1 and disease arising from reactivation of latent virus: To determine the role of EWSR1 repression during latent infection, we inoculated wild-type B6 mice with MHV68.EW.shR or MHV68.SC.shR, or with parental wild-type virus MHV68.WT, and then quantified features of chronic infection, including spleen weights and the frequency of latently infected cells.