Notably though, while the splenomegaly induced by virus recombinants expressing scrambled shRNAs in place of pre-miR-7 and pre-miR-12 stem-loops was substantially reduced (117 mg) compared to wild-type virus, the expression of anti-EWSR1 shRNAs restored this attenuation (159 mg). Here, EWSR1 is linked to Splenomegaly.