Consistent with the previous study demonstrating that cytosolic WDR76 is involved in the destabilization of H-RAS and the suppression of transformation in HCC [19], GFP-WDR76ΔNLS was more effective than GFP-WDR76FL in reducing K-RAS and pan-RAS protein levels (Additional file 1: Figure S4A). This evidence concerns the gene KRAS and hepatocellular carcinoma.