To identify whether a certain subcellular fraction of WDR76 is involved in K-RAS destabilization in CRC, we overexpressed full-length GFP-WDR76 and a nuclear localization signal (NLS)-deleted mutant of GFP-WDR76 (FL and ΔNLS, respectively) in D-MT cells. The gene discussed is WDR76; the disease is colorectal carcinoma.