We examined the phenotypes of Wdr76-knockout (Wdr76−/−) mice [19] and found that loss of Wdr76 did not induce tumor formation in 15-week-old mice; however, it induced significant crypt lengthening and hyper-proliferation (Fig. 1b, c, Additional file 1: Figure S2A), which are characteristics of mice that harbor oncogenic K-Ras mutations [13]. This evidence concerns the gene KRAS and neoplasm.