APC and colorectal carcinoma: A strong positive correlation between β-catenin and pan-Ras expression levels in tumors of ApcMin/+; K-RasG12DLA2 mice (Fig. 3c) confirmed the importance of RAS stabilization in the positive crosstalk between the Wnt/β-catenin and RAS pathways in CRC harboring both APC mutations and oncogenic K-RAS mutations.