Conversely, synaptic long-term potentiation, α-adrenergic and β-adrenergic signaling, androgen and aldosterone signaling, ephrin receptor signaling, relaxin signaling, dopamine-DARPP32 feedback signaling, dopamine receptor signaling, eNOS and nNOS signaling, somatostatin receptor 2 signaling, neurotrophin/TRK signaling, protein ubiquitination pathway, gap junction signaling, phototransduction pathway, and several other pathways were associated with baseline refractive development but not susceptibility to myopia. The gene discussed is PPP1R1B; the disease is myopia.