Conversely, synaptic long-term potentiation, α-adrenergic and β-adrenergic signaling, androgen and aldosterone signaling, ephrin receptor signaling, relaxin signaling, dopamine-DARPP32 feedback signaling, dopamine receptor signaling, eNOS and nNOS signaling, somatostatin receptor 2 signaling, neurotrophin/TRK signaling, protein ubiquitination pathway, gap junction signaling, phototransduction pathway, and several other pathways were associated with baseline refractive development but not susceptibility to myopia. This evidence concerns the gene NOS3 and myopia.