Analysis of the canonical pathways influenced by the genes correlated with susceptibility to myopia revealed that increased susceptibility to myopia was associated with suppression of mTOR signaling, EIF2 signaling, protein kinase A signaling, D-myo-inositol-5-phosphate metabolism, cholesterol and choline biosynthesis, as well as with activation of amyloid processing, HIPPO signaling, PTEN signaling, and PPARα/RXRα signaling pathways (Fig. 3c, Additional file 3: Table S8). The gene discussed is PPARA; the disease is myopia.