PLCG1 and neoplasm: Multivariate analysis showed that high expression of PLCγ1-pY1253 was an independent prognostic marker for DRFS in Luminal-B tumours (HR, 2.3; 95% CI, 1.2–4.6; P = 0.017), while only high expression of PLCγ1-pY783 was correlated with significantly higher risk of distant relapse in patients with Luminal-A tumours (HR, 7.4; 95% CI, 2.3–24.3; P = 0.001) (Additional file 1: Table S2).