CXCR4 and breast carcinoma: In the treated mice (4T1-induced Balb/c mouse model of breast cancer), according to the results previously reported on the breast cancer cell lines MCF-7, MDA-MB-231 and 4T1, U. dioica treatment induced the anti-metastatic pathway, with decreased expression of miR-21, MMP1, MMP9, MMP13, vimentin and CXCR4 and increased expression of E-cadherin (Mansoori et al. 2017) [131].