MMP9 and neoplasm: In detail, demonstrated that U. dioica extract could inhibit tumor metastasis by regulating miR-21 (a crucial oncomir that is overexpressed in advanced tumors and metastasis) [140,141,142,143,144,145,146], the matrix metalloproteinases [147] MMP1, MMP9, MMP13, the vimentin [148], CXCR4 [149,150] and E-cadherin [151], important metastasis-related genes involved in cellular invasion by modifying adhesion junctions and the migratory capacity of cells [152].