The plasma membrane receptor in podocytes, through which AOPPs induce their action, is the receptor of advanced glycation end product (RAGE), a member of the IG superfamily and a multiligand signal–transduction receptor, which has been implicated in diabetic nephropathy as well as inflammation and ischemia/reperfusion injury [53,54,55,56,57]. The gene discussed is AGER; the disease is diabetic kidney disease.