In early dumping syndrome, rapid transition of food into the small intestine results in a fluid shift (due to hyperosmolarity) and release of gastrointestinal hormones such as vasoactive substances (neurostatin, vasoactive intestinal peptide (VIP), incretins (gastric inhibitory polypeptide (GIP), GLP1) and glucose-modulators (insulin, glucagon) [2,15,41,42,43]. This evidence concerns the gene VIP and dumping syndrome.