They inferred that the underlying mechanism of periplocin against heart failure might involve its ability to increase the expression of sarco endoplasmic reticulum Ca2+-ATPase mRNA, decrease the expression of phospholamban mRNA and improve the value of PLB/SERCA in chronic heart failure-model rats [122] The proliferative activity of periplocin was verified in mouse cardiac microvascular endothelial cells by Gao and co-workers [123]. This evidence concerns the gene PLN and heart failure.