ACE and cancer: It metabolizes structurally diverse compounds such as the psychostimulant methylphenidate (MPH) [8] used in the treatment of hyperkinetic disorders, commonly prescribed angiotensin-converting enzyme (ACE) inhibitors (enalapril, trandolapril, ramipril, quinapril, imidapril) [9], the anti-cancer agent (CPT-11) [10,11], the anti-influenza prodrug oseltamivir [12], and several narcotics and analgesics (cocaine, meperidine) [13,14].