ERVW-1 and AIDS dementia complex: In an analysis of fours HERV families in the brain of neuroAIDS patients (HERV-W, HERV-K, HERV-E, and HERV-H) [82], a significant upregulation of HERV-W and HERV-K RNA was detected in brain tissue from patients with AIDS dementia, the expression of HERV-H was slightly increased, while that of HERV-E was significantly reduced.