TARDBP and amyotrophic lateral sclerosis: There are several ALS-associated mutations: SOD-1 (superoxide dismutase), TAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa), C9orf72 (chromosome 9 open reading frame 72) protein, RNA-binding protein FUS/TLS (Fused in Sarcoma/Translocated in Sarcoma), etc. The multiple pathogenic mechanisms of ALS (including TDP-43 mutations) share cytoplasmic TDP-43 deposits as a common trait, which are thought to be critical in the degenerative process of motor neurons, and considered the final hallmark of ALS.