Twenty-four different transcribed HML-2 loci were identified in brain and spinal cord tissue samples from ALS patients and controls [71], by generating and mapping HML-2-specific cDNA sequences, without significant differences between ALS and controls, and opened up the possibility that HML-2 proteins other than canonical full-length Env may have to be considered when studying the role of HML-2 in ALS disease [71]. This evidence concerns the gene CLEC10A and amyotrophic lateral sclerosis.