VEGFA and peripheral arterial disease: The mouse hind limb ischemia model and PAD patients frequently show similar neovascularization patterns with arteriogenic responses that are close to the occlusions to form collaterals arteries and an angiogenic response in the distal ischemic tissue, as was illustrated by comparing the angiogenic response and VEGF expression in the muscle biopsies of CLI patients and mice after induction of HLI [31,44,45].