CAV1 and cancer: Given the wide variety of cellular processes that are modulated by CAV1 (caveolae), it is not surprising that this protein is involved in the development of many pathologies, such as cardiac hypertrophy, heart failure, fibrosis diseases, insulin resistance [38] and age-related diseases, such as atherosclerosis, osteoarthritis, pulmonary emphysema [39], and particularly cancer and metastatic disease [29].