PTGS2 and malignant colon neoplasm: Our findings in colon cancer cells expressing E-cadherin indicate that CAV1 promotes the sequestration of β-catenin to the plasma membrane and thereby prevents β-catenin/(T-cell factor) Tcf-Lef dependent transcription of survivin and cyclo-oxygenase-2 (COX-2), both implicated in tumor development, progression, inflammation and angiogenesis [61,62,63,64].