Moreover, in murine melanoma B16F10 cells expressing low levels of CAV1 and E-cadherin levels, transfection with plasmids encoding CAV1, E-cadherin, or both proteins revealed that expression of either protein individually decreased the ability of B16F10 cells to form subcutaneous tumors in syngeneic C57BL/6 mice. The gene discussed is CDH1; the disease is melanoma.