In this regard, Cyr61, a member of the CCN (connective, cysteine, nephroblastoma) family of matricellular proteins that also includes connective tissue growth factor (CTGF) [177,178] is of interest given that Cyr61 promotes the migration, growth, and invasion of tumor cells in gastric, breast, and ovarian cancers [179,180]. The gene discussed is CCN2; the disease is neoplasm.