CAV1-containing conditioned media (CM) from high passage CAV1-secreting, human prostate cancer LNCaP (LNCaPCAV1) cells augmented viability and clonal growth of low passage, CAV1-negative, LNCaP cells in vitro, and addition of CAV1-specific antibodies to the CM blocked this effect. The gene discussed is CAV1; the disease is Familial prostate cancer.