EMT is critical in cancer progression and metastasis, and involves the downregulation of epithelial markers (e.g., E-cadherin and γ-catenin), upregulation of mesenchymal markers (e.g., vimentin, fibronectin and N-cadherin) and transcription factors (e.g., Snail and Slug), which in conjunction enhance invasion, migration, and the acquisition of stem cell-like properties of cancer cells [90]. Here, CDH2 is linked to cancer.