We found that incubation of the 3D cultures with the anti-PRG4 mAb 4D6, but not with mouse IgG control, decreased the ability of rhPRG4 to suppress TGFβ-induced deformation in the growth of the 3D-breast cancer cell-derived organoids (Fig 1C and 1D). The gene discussed is PRG4; the disease is breast carcinoma.