Consistent with the above data, elevated levels of progranulin, along with a strong expression of p‐STAT3 Tyr705, were observed in the human CRC cell lines HCT‐116 and HT‐29, whereas both proteins were barely detectable in the human normal colonic epithelial cell line HCEC‐1CT (Fig. 1C). This evidence concerns the gene STAT3 and colorectal carcinoma.