Indeed, knockdown of progranulin in CRC cell lines associates with reduced proliferation and arrest of cells in the S phase of the cell cycle, as well as with a marked and specific downregulation of cyclin D1 and CDC25A, two pivotal mitogenic proteins overexpressed and positively regulated by constitutively active STAT3 in CRC (Carpenter and Lo, 2014). The gene discussed is GRN; the disease is colorectal carcinoma.