Altogether, these findings suggest that NF‐kB/p65‐activating factors secreted within the tumor microenvironment can enhance progranulin synthesis and consequently promote STAT3 activation, thus adding another piece of evidence supporting the dangerous liaison between STAT3 and NF‐kB in colon carcinogenesis (Grivennikov and Karin, 2010). Here, STAT3 is linked to neoplasm.