Initially, we performed immunoprecipitation of whole‐cell extracts from HCT‐116 and HT‐29 cells using an anti‐STAT3 antibody followed by immunoblotting analysis with an anti‐progranulin antibody and showed that progranulin physically interacted with STAT3 in CRC cells (Fig. 2A). Here, STAT3 is linked to colorectal carcinoma.