Progranulin protein content was significantly increased in CRC samples as compared with the nontumor mucosa, as confirmed by densitometry analysis of the blots (Fig. 1A), and positively correlated with p‐STAT3 Tyr705 expression (r = 0.8313, P < 0.001) (Fig. 1B). This evidence concerns the gene STAT3 and colorectal carcinoma.