To link our in vitro observations to primary human cells, we isolated tumor‐infiltrating leukocytes (TILs) from the tumor area of patients who underwent surgery for CRC and assessed whether TIL‐derived culture supernatants could modulate STAT3 activation and cell proliferation in HCT‐116 and HT‐29 cells transfected with either progranulin or control ASO. This evidence concerns the gene STAT3 and neoplasm.