However, in support of progranulin knockdown‐based strategies are findings indicating a role of ASO‐mediated STAT3 silencing in promoting immunosurveillance by both increasing the immunogenicity of cancer cells via cell‐autonomous pathways and favoring the reprogramming of the tumor microenvironment toward an immunostimulatory state (Hong et al., 2015). Here, STAT3 is linked to neoplasm.