SMYD3 and renal cell carcinoma: Among the genes showing CNV, three (PTK7, EGLN1, SMYD3) have been reported to be related to RCC or cancer cell invasion.14 Gain of PTK7 is observed in three of 51 cases (5.9%) of localized‐stage and 18 of 35 cases (51.4%) of advanced‐stage type 2 PRCC, and survival analysis demonstrates that PTK7 gain is associated with poor survival (P < 0.0001).