RHOA and cancer: In the RCC cell line RCC7, acute activation of the β2‐adrenergic receptor‐regulated cancer cell migration occurs by promoting RhoA activation and influencing focal adhesion formation.18 G protein‐coupled receptors (GPCRs) play critical roles in the invasion and metastasis of cancer cells by activating Rho GTPases, and regulating cytoskeletal remodeling and angiogenesis.