Mutations in KCNH2 induce long QT syndrome type 2 (LQT2), which can lead to ventricular arrhythmias, syncope and sudden death.1 The KCNH2 channel contains six transmembrane segments (S1‐S6) with S1‐S4 contributing to the voltage sensor domain (VSD) and S5‐S6 along with the intervening pore loop contributing to the pore domain. Here, KCNH2 is linked to Ventricular arrhythmia.