As of date, CCM1 (KRIT1) on chromosome 7q, CCM2 (MGC4607/OSM/Malcavernin) on chromosome 7p, and CCM3 (PDCD10/TFAR15) on chromosome 3q are genes that are known to cause the familial form of CCM. This evidence concerns the gene PDCD10 and cerebral cavernous malformation.