We have previously reported that the oncoprotein transcription factor MYC is recruited to chromatin through its interaction with WDR5 (which is mediated via a surface of WDR5 distinct from the WIN site).13 MYC promotes transcription of almost all ribosome subunits, as well as many ribosome biogenesis factors.14 As MYC levels rise in a nascent cancer cell, the avidity provided by WDR5 could cause a preferential activation of WDR5-bound RPGs, resulting in an excess of these subunits. The gene discussed is MYC; the disease is cancer.