CHEK2 and breast cancer: We then investigated the clinicopathologic and genomic profiles of a set of 17 CHEK2-associated BCs from patients carrying the low-risk p.Ile157Thr germline variant, which has been associated with an approximate 1.5-fold increase in BC risk (Figure 1A;, Supplementary Tables 1 and 2, Supplementary Figure 6, available online) (3,4).