CHEK2 and cancer: We sought to define the phenotypic characteristics and somatic genetic alterations of BCs with germline CHEK2 variants by pooling whole-exome sequencing (WES) data from The Cancer Genome Atlas (TCGA) (9) and targeted sequencing data from Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT; Supplementary Figure 1 and Table 1, available online).