Tissue microarray analysis was performed on tissues obtained from a prostatectomy cohort and revealed statistically and biologically significant reductions of BHMT (P = .0003; Figure 2C), and CBS (P < .0001; Figure 2D) in AA PCa relative to EA PCa, thereby validating accumulation of homocysteine in AA PCa (Supplementary Figure 5, available online, shows the cumulative frequency of TMA scores). Here, CBS is linked to posterior cortical atrophy.