This eight-gene signature comprised seven protective genes (high expression in low-risk melanomas): keratin 9 (KRT9), dermcidin (DCD), prolactin-induced protein (PIP), secretoglobin family 1D member 2 (SCGB1D2), secretoglobin family 2A member 2 (SCGB2A2), collagen alpha6(VI) (COL6A6), guanylate binding protein 4 (GBP4), and one risk gene (high expression in high-risk melanomas): kelch-like family member 41 (KLHL41). Here, PIP is linked to melanoma.