Other signature genes are involved in immune responses and inflammation, for example, KRT9 in the Wnt/β-catenin signaling pathway (15) and COL6A6 in ostheoarthritis (16); GBP4 is upregulated by interferon in colon carcinoma, coordinately with the immune checkpoints PD-1/PD-L1 (17). Here, GBP4 is linked to colon carcinoma.