Expression of this reporter plasmid, pCAT-3'UTR (SAF1), in response to ectopic overexpression of miR-125b RNA was found to be substantially decreased in normal breast epithelial MCF-10A cells and in several breast cancer cells including ER positive MCF-7 and ZR-75-1 and ER-negative SKBR3 and BT-549 cells (Figure 1B). Here, MAZ is linked to breast cancer.