A similar effect was also observed in the staining of phosphorylated Akt (pSer473Akt) in human PCa tissues, where a decreased expression of pSer473Akt in high Gleason score (5+5) PCa tissues was observed compared to low Gleason score samples (3+3), particularly in the proliferating luminal cells (Figure 8G-H). Here, AKT1 is linked to posterior cortical atrophy.