Exome sequencing by the Broad/Cornell group on the human prostate adenocarcinoma [23] showed only 15% of the patients with genetic alterations in the PI3K/Akt pathway, out of which 7% alterations were in PTEN and a single case of missense mutations was observed in Akt1 and Akt3 isoforms. The gene discussed is PTEN; the disease is prostate adenocarcinoma.