Whereas Akt inhibition by MK-2206 in vitro promoted NSCLC invasion and metastasis through the activation of MARCKs-LAMC2 [17], Akt inhibition by triciribine promoted PCa EMT and metastasis in a neuroendocrine mouse model of TRAMP [13]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.