Intriguingly, although not significant, there was a strong trend correlating increased TGFβ1, Snail and CDH2 levels in the higher (N=206) compared to the lower Gleason score group (N=292) (Figure 9E-H), indicating that the suppression of Akt1 activity in advanced PCa could promote EMT and metastasis. This evidence concerns the gene SNAI1 and posterior cortical atrophy.