Datasets (in cBioPortal and GENIE) from prostate, breast, colorectal, bladder, ovarian, uterine, head-and-neck squamous cell carcinoma, melanoma, and esophago-gastric cancers were included (Table 1); other tumor types did not reach a 1% frequency of CDK12 alterations. The gene discussed is CDK12; the disease is head and neck squamous cell carcinoma.