It had been reported that obesity mothers who carried mutant genotype AC for glutamate-cysteine ligase, catalytic subunit (GCLC) gene (rs6458939) significantly increased the risk of conotruncal defects (CTDs) in infants, compared with those obesity mothers who carried the CC genotype [58]. The gene discussed is GCLC; the disease is obesity due to melanocortin 4 receptor deficiency.