Conversely, activation of Th2-polarised CD4+ T-helper cells results in expression of inflammatory cytokines (IL-4, IL-5, IL-6, IL-10, and IL-13), which then enhances humoral immunity and downregulates cell-mediated anti-tumour immunity; thereby, promoting the pro-tumour humoral response.18,21, , –24. This evidence concerns the gene IL10 and neoplasm.