Dysregulation of APE1 has been demonstrated to be associated with a couple of diseases such as cancer,4 neurodegenerative diseases5 and cardiovascular disorders.6 Abnormal expression and subcellular distribution of APE1 have been linked to tumor metastasis.7 From a therapeutic perspective, APE1 has drawn significant attention as an emerging target for some cancer types.4 This motivates fabricating molecular tools to probe and regulate the cellular APE1 activity. Here, APEX1 is linked to neoplasm.