Furthermore, the combination of cisplatin and quercetin was also been shown to induce synergistic arrest of the cell cycle at S phase in human malignant mesothelioma cells (SPC212 and SPC111) [21], and at G0/G1 phase, by elevation of p16INK4A expression in human hepatocellular carcinoma cells (HepG2) [24]. The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.