Fan et al (2012) showed that transcription factors of EMT (Snail and Twist) confer a CSC phenotype by inducing the expression of pluripotency maintaining transcription factors associated with stem cells, such as Oct3/4, Sox2, Nanog in CRC cell lines HT29 and HCT116 [27]. The gene discussed is SNAI1; the disease is colorectal carcinoma.