Such dysfunction of GPR120 could be a potential mechanism for HFD-induced obesity and obesity-associated metabolic syndrome in mice (28), and the expression of GPR120 in X/A-like cells causes a reduced level of ghrelin (79−81), suggesting that the activation of GPR120 has an anti-obesity effect. This evidence concerns the gene FFAR4 and obesity due to melanocortin 4 receptor deficiency.